Insulin and postprandial vascular function Postprandial Vascular Effects of Viaject compared with Insulin Lispro and Regular Human Insulin in Patients with Type 2 Diabetes Mellitus Running title: Insulin and postprandial vascular function
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چکیده
Running title: Insulin and postprandial vascular function Thomas Forst MD; Andreas Pfützner MD, PhD; Frank Flacke PhD; Alan Krasner MD; Cloth Hohberg MD; Eda Tarakci; Philip Pichotta PhD; Senait Forst; Solomon Steiner PhD Corresponding Author: Thomas Forst, MD Email: [email protected] Clinical trial reg. no. NCT00849576; www.clinicaltrials.gov Submitted 3 March 2009 and accepted 16 September 2009. This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes Care in print and online at http://care.diabetesjournals.org. Diabetes Care Publish Ahead of Print, published online October 6, 2009
منابع مشابه
Postprandial Vascular Effects of VIAject Compared With Insulin Lispro and Regular Human Insulin in Patients With Type 2 Diabetes
OBJECTIVE Recent studies suggested an impact of prandial insulin delivery on postprandial regulation of tissue blood flow. This study compared the effect of VIAject with human regular insulin and insulin lispro on postprandial oxidative stress and endothelial function in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Fourteen patients (seven men; aged 61.5 +/- 1.8 years; duration ...
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OBJECTIVE To assess the relative importance of fasting and postprandial hyperglycemia to vascular dysfunction in diabetes, we have measured indicators of glycation, oxidative and nitrosative stress in subjects with type 1 diabetes, and different postprandial glucose patterns. RESEARCH DESIGN AND METHODS Plasma and urinary levels of specific arginine- and lysine-derived advanced glycation end ...
متن کاملRenal and metabolic effects of insulin lispro in type 2 diabetic subjects with overt nephropathy.
OBJECTIVE To assess whether the insulin analog lispro may antagonize the renal effects of IGF-1, a mediator of glomerular hyperfiltration involved in the progression of diabetic and nondiabetic chronic nephropathies. RESEARCH DESIGN AND METHODS In a randomized crossover study, we compared the renal and metabolic responses to regular or lispro insulin (0.1 units/kg body wt) administered after ...
متن کاملReduction of postprandial glycemic excursions in patients with type 1 diabetes: a novel human insulin formulation versus a rapid-acting insulin analog and regular human insulin.
BACKGROUND Evaluation of postprandial glycemic excursions in patients with type 1 diabetes with three prandial insulins: VIAject™ (Linjeta™), an ultra-fast insulin (UFI); insulin lispro (LIS); and regular human insulin (RHI). METHODS After stabilization of preprandial glycemia, 18 patients received a subcutaneous injection with an individualized insulin dose prior to a meal. RESULTS Injecti...
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Insulin lispro, an insulin analog recently developed particularly for mealtime therapy, has a fast absorption rate and a short duration of action. We compared insulin lispro and regular human insulin in the mealtime treatment of 1,008 patients with IDDM. The study was a 6-month randomized multinational (17 countries) and multicenter (102 investigators) clinical trial performed with an open-labe...
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